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In adipose tissue, HIF activation can improve IR by stimulating the thermogenic function of brown adipose tissue (BAT) by regulating mitochondrial biogenesis and glycolysis

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Hepatic IGF-1 production responds to cumulative GH exposure, making it a practical endpoint for monitoring treatment effect

While direct evidence in the context of GLP-1RA remains limited, these approaches may enable identification of early molecular signatures of treatment response and stratify patients based on underlying plaque biology